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Hepatolithiasis is characterised by the presence of intrahepatic gallstones. These calculi can lead to cholangitis, progressive hepatocyte atrophy and destruction, and an increased risk of cholangiocarcinoma. It is common in East Asia but rare in Western countries. There is no difference in incidence between genders. The stones are most commonly made up of pigmented calcium bilirubinate stones.
These stones cause intrahepatic bile duct obstruction. Proximal to the obstructing stone distension and dilation of the bile ducts is evident. There is also bile duct proliferation at the portalparenchymal interface with stromal oedema and infiltrating neutrophils, indicating an acute-chronic inflammation. If untreated this inflammation leads to periportal fibrosis and eventually obstructive biliary cirrhosis. Microscopic appearance would show feathery degeneration of periportal hepatocytes, cytoplasmic swelling often with Mallory Denk bodies (i.e. an inclusion found in the cytoplasm of liver cells with twisted-rope appearance caused by damaged intermediate filaments within the hepatocytes) and bile infarcts from extravasated bile. Chronic inflammation can lead to biliary dysplasia which may develop into cholangiocarcinoma. Patients may present with repeated cholangitis, intermittent abdominal pain, jaundice or frequently no symptoms. Treatment is usually surgical removal of the calculi.
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