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RVH usually occurs due to chronic lung disease or structural defects in the heart. One of the most common causes of RVH is pulmonary hypertension (PH), which leads to increased pulmonary artery pressure. As the right ventricle tries to compensate for this increased pressure it changes its shape and size causing hypertrophy and right ventricular wall thickness. The global incidence of PH is 4 per 1M people: RVH occurs in approximately 30% of these cases. Common causes of PH include chronic obstructive pulmonary disease (COPD), pulmonary embolism, and other restrictive lung diseases. RVH also occurs in response to structural defects in the heart, such as tricuspid insufficiency, which allows the backward flow of blood into the ventricle. Other structural defects that lead to RVH include tetralogy of Fallot, ventricular septal defects, pulmonary valve stenosis, and atrial septal defects. RVH is also associated with abdominal obesity and high systolic blood pressure.
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