Metastatic Adenocarcinoma in the Brain

Features:

Clinical History

A 56-year old male underwent a total gastrectomy and splenectomy for gastric adenocarcinoma. Over a period of two months he developed a progressively unsteady gait, increasing weakness of his left hand and frontal headaches associated with nausea and vomiting. Imaging revealed a lesion in the right frontal lobe. He underwent a craniotomy with resection of the lesion, which was confirmed metastatic gastric adenocarcinoma. He experienced gradual increasing symptoms as well as jaundice, deteriorating consciousness and papilloedema from increased intracranial pressure. Repeat imaging revealed recurrence of the right frontal metastatic lesion as well as liver metastases. The patient died 9 months after his initial gastrectomy surgery.

Pathology